MalwareDomains.com provides a DNS blocklist of known malware domains. This list is natively used as a part of DNS configuration, however, the below tool will allow you to import the domains.txt definitions file into ISA Server as a URL Set or DNS Set. You can then create a deny access rule based on the imported list.

Note that I have not tested this application yet, so use at your own risk

Check it out at:

http://sync-io.net/ISATools.aspx

HTH,

Tom

Thomas W Shinder, M.D.
Site: http://www.isaserver.org/
Blog: http://blogs.isaserver.org/shinder/
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Email: tshinder@isaserver.org
MVP — Microsoft Firewalls (ISA)